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Lack of Sleep May Raise Risk of Diabetes

 
07-24-2012  |  By: Fidelis Diagnostics, Inc |  (0) Post comment »  |  Read comments »
 

I just read a very interesting article by Michael Smith, North American Correspondent for  MedPage Today which I wanted to share with you.

It seems that what we all knew to be bad for us is actually bad for us... In a 39-day experiment with healthy volunteers, shortened sleep time and varying bedtimes -- meant to mimic shift work -- led to impaired glucose regulation and metabolism, according to Orfeu Buxton, PhD, of Brigham and Women's Hospital in Boston, and colleagues.

 "Since night workers often have a hard time sleeping during the day, they can face both circadian disruption working at night and insufficient sleep during the day," Buxton said in a statement. "The evidence is clear that getting enough sleep is important for health, and that sleep should be at night for best effect."

The combination of not enough sleep and circadian rhythm disruption caused a marked decrease in insulin secretion in response to the meal, the researchers reported. The combination of not enough sleep and circadian rhythm disruption caused a marked decrease in insulin secretion in response to the meal, the researchers reported.

In other words impaired sleep led to problems in sugar metabolism and could increase the risk of obesity and of developing diabetes!

So, make sure that you get enough sleep on a regular basis and let me misqoute a famous saying,

Early to bed and rested when you rise,

Will make you healthy, happy and wise!

 

Have a restful summer,

Miriam Rotman MD

 

Correlates of Diabetic Foot Complications Identified

 
07-10-2012  |  By: Fidelis Diagnostics, Inc |  (0) Post comment »  |  Read comments »
 
Correlates of Diabetic Foot Complications Identified

By Dr. Miriam Rotman
This week's blog is for physicians -

For patients with diabetes, increased poly(ADP-ribose) (PAR) immunoreactivity, reduced abundance of type 1 procollagen, and impaired skin structure correlate with foot complications, according to a study published online June 29 in Diabetes Care.

Abd A. Tahrani, M.D., from the University of Birmingham in the United Kingdom, and colleagues examined whether high-risk patients exhibit skin structural and metabolic deficits that predispose to foot complications. Participants included nine control patients with diabetes, 16 patients with diabetic peripheral neuropathy (DPN) alone, 21 with recurrent diabetic foot ulceration (DFU), and 14 controls without diabetes. Intra-epidermal nerve fiber density (IENFD), structural analysis, type 1 procollagen abundance, tissue degrading matrix metalloproteinases (MMPs), and PAR immunoreactivity were measured using skin punch biopsies from the upper and lower leg skin.

The researchers found that diabetes and DPN decreased IENFD, with no difference noted between the neuropathic groups. In neuropathic subjects, especially in the DFU group, skin structural deficit scores were increased. Compared with controls without diabetes, individuals with DFUs had reduced abundance of type 1 procollagen. Activation of MMP-1 and MMP-2 was seen with diabetes. Compared with other DPN patients, those with DFU had increased PAR immunoreactivity.

"In conclusion, increased PAR polymerase, reduced type 1 procollagen, and impaired skin structure are associated with the development of foot complications in diabetes and may constitute novel biomarkers to identify patients at maximal risk," the authors write. "Therapies aimed at improving skin quality also warrant consideration as an approach to reduce DFU."

Wonderful free resource from the American Diabetes Association for Physicians -

The Where Do I Begin? booklet is the first step to helping patients get the information they need at diagnosis. You can order free copies of Where Do I Begin? and give this great resource to your newly diagnosed patients. Encourage patients to take the next step and enroll in the free program to get ongoing information and support over their first year living with type 2 diabetes.
To order free copies, visit diabetes.org/atdx.